An interesting best-of-times-worst-of-times story related to migraine treatment can be found in a humble wheat mold, called ergot. Early last century pharmaceutical companies got interested in ergot and took two dramatically different roads in their attempt to develop drugs based on the effects of the mold. One road led to the development of a drug with great social effect, seemed to work for everybody, made very little money and was eventually deemed illegal. Ironically, the other drug remained legal, made a great deal of money and had highly variable efficacy. You may have taken one and possibly both of these drugs in your lifetime.